The purpose of this study is to observe the changes of pulmonary capillary permeability and various hemodynamic parameters before and after Positive End-Expiratory Pressure(PEEP) in Adult Respiratory Distress Syndrome (ARDS).
Using a canine oleic acid induced ARDS model, we measured the pulmonary capillary permeability with a slope of lung: heart radioactivity ratio, hemodynamic parameters with Swan-Ganz catheter and blood gas tensions.
1) In normal and ARDS dogs, the PEEP didn´t significantly influence the slope of lung: heart radioactivity ratio. But in ARDS group the slope index was increased compaired with that of control group (p<0.05).
3) Also in ARDS group, PaO, was significantly decreased, and PaC02i PvCO2, MPAP, AaDO2, Qs/Qt were significantly increased compared with those of control group (p<0.05).
3) In normal dogs, the PEE: didn´t influence blood pH or gas tension, AaD02, Qs/Qt, or hemodynamics.
4) In ARDS dogs, however, the PEEP significantly increased Pa02i and decreased AaD02, Qs/Qt (p<0.05).
|